Hantavirus regulation of endothelial cell functions
| Autor: | Erich R. Mackow, Irina N. Gavrilovskaya |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Orthohantavirus
Pathology medicine.medical_specialty Endothelium Angiogenesis Hantavirus Infections animal diseases viruses Vascular permeability Hantavirus Pulmonary Syndrome Biology Models Biological Capillary Permeability Pathogenesis Antigens CD Cricetinae medicine Animals Humans Hantavirus Hantavirus pulmonary syndrome Mesocricetus Integrin beta3 Endothelial Cells virus diseases Hematology Cadherins respiratory tract diseases Endothelial stem cell Disease Models Animal medicine.anatomical_structure Hemorrhagic Fever with Renal Syndrome Host-Pathogen Interactions Immunology Receptors Virus Interferons Hantavirus Infection |
| Zdroj: | Thrombosis and Haemostasis. 102:1030-1041 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th09-09-0640 |
| Popis: | SummaryHantaviruses cause two vascular permeability-based diseases and primarily infect endothelial cells which form the primary fluid barrier of the vasculature. Since hantavirus infections are not lytic, the mechanisms by which hantaviruses cause haemorrhagic fever with renal syndrome (HFRS) or Hantavirus Pulmonary Syndrome (HPS) are indeterminate. HPS is associated with acute pulmonary oedema and HFRS with moderate haemorrhage and renal sequelae, perhaps reflecting the location of vast microvascular beds and endothelial cell reservoirs available for hantavirus infection. Endothelial cells regulate capillary integrity, and hantavirus infection provides a primary means for alteing vascular permeability that contributes to pathogenesis. The central importance of endothelial cells in regulating oedema, vascular repair, angiogenesis, immune cell recruitment, platelet deposition as well as gas exchange and solute delivery suggest that a multitude of inputs and cellular responses may be influenced by hantavirus infection and contribute to pathogenic changes in vascular permeability. Here we focus on understanding hantavirus interactions with endothelial cells which are linked to vascular permeability, and provide insight into the contribution of endothelial cell responses in hantavirus pathogenesis. |
| Databáze: | OpenAIRE |
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