Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia
| Autor: | Wataru W. Sutow, James T. Lowman, Kenneth A. Starling, Mary Ellen Haggard, G. B. Humphrey, Teresa J. Vietti, Stephen L. George |
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| Rok vydání: | 1976 |
| Předmět: |
Cancer Research
Vincristine medicine.medical_specialty Adolescent Childhood leukemia Daunorubicin medicine.medical_treatment Gastroenterology Drug Hypersensitivity Prednisone Internal medicine Asparaginase Humans Medicine Child Response rate (survey) Acute leukemia Chemotherapy Leukemia business.industry Infant medicine.disease Regimen Oncology Child Preschool Hyperglycemia Acute Disease Pediatrics Perinatology and Child Health Immunology Drug Evaluation business medicine.drug |
| Zdroj: | Medical and Pediatric Oncology. 2:387-395 |
| ISSN: | 1096-911X 0098-1532 |
| Popis: | Six regimens utilizing L-asparaginase in doses of 6,000 IU/M2, 2,000 IU/M2, and 500 IU/M2 in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse. The addition of daunorubicin to one regimen did not alter the response rate. Hypersensitivity reactions occurred in 5% and hyperglycemia in 7%. Lower doses of L-asparaginase significantly reduced the hypersensitivity rate but no such pattern was noted for hyperglycemia. A history of prior resistance to prednisone and vincristine significantly reduced the response rate. |
| Databáze: | OpenAIRE |
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