The negative effects of social bond disruption are partially ameliorated by sertraline administration in prairie voles
| Autor: | Ashley Dagner, Angela J. Grippo, W Tang Watanasriyakul, Oreoluwa I Akinbo, Marigny C Normann, Elliott Ihm, Neal McNeal, Joshua Wardwell |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Physiology Autonomic Nervous System Article 03 medical and health sciences Cellular and Molecular Neuroscience Social support 0302 clinical medicine Heart Rate Sertraline Heart rate Animals Medicine Heart rate variability Social stress Pair Bond biology Arvicolinae Depression Endocrine and Autonomic Systems business.industry Stressor Brain biology.organism_classification Autonomic Agents Prairie vole Social Isolation Neurology (clinical) Serotonin business Stress Psychological 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Auton Neurosci |
| ISSN: | 1566-0702 |
| Popis: | Negative social experiences influence both depression and cardiovascular dysfunction. Many individuals who experience negative mood states or cardiovascular conditions have limited social support. Therefore, investigation of drug treatments that may protect against the consequences of social stress will aid in designing effective treatment strategies. The current study used an animal model to evaluate the protective effect of sertraline administration on behavioral and cardiovascular consequences of social stress. Specifically, male prairie voles (Microtus ochrogaster), which are socially monogamous rodents that share several behavioral and physiological characteristics with humans, were isolated from a socially-bonded female partner, and treated with sertraline (16 mg/kg/day, ip) or vehicle during isolation. Unexpectedly, sertraline did not protect against depression-relevant behaviors, and it was associated with increased short- and long-term heart rate responses. However, sertraline administration improved heart rate variability recovery following a behavioral stressor, including increased parasympathetic regulation, and altered long-term neuronal activity in brain regions that modulate autonomic control and stress reactivity. These results indicate that sertraline may partially protect against the consequences of social stressors, and suggest a mechanism through which sertraline may beneficially influence neurobiological control of cardiac function. |
| Databáze: | OpenAIRE |
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