The effects of desipramine (DMI) and alpha-2 adrenoceptor agonists on flexor reflex activity (FRA) in the spinalized and decerebrate rat
| Autor: | A. Rawlow, R. G. King |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Withdrawal reflex Norepinephrine Cordotomy Desipramine Internal medicine Reflex medicine Prazosin Animals Neurotransmitter Uptake Inhibitors Biological Psychiatry Adrenergic alpha-Antagonists Spinal Cord Injuries Decerebrate State Chemistry Rats Inbred Strains Electric Stimulation Yohimbine Clonidine Rats Psychiatry and Mental health Endocrinology Neurology Decerebration Alpha-2 adrenergic receptor Neurology (clinical) Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | Journal of neural transmission. General section. 84(1-2) |
| Popis: | In the spinalized and decerebrate rat, electrically evoked flexor reflex activity (FRA) of the right anterior tibialis muscle was facilitated by DMI (0.1-3 mg/kg i.v.). DMI (3 mg/kg i.v.) had not effect on twitches of the left ant. tib. muscle evoked by electrical stimulation of the distal stump of the severed sciatic nerve (directly evoked twitches). The alpha-1 adrenoceptor antagonist prazosin (300 micrograms/kg i.v.) and the alpha-2 adrenoceptor agonists clonidine (5 and 10 micrograms/kg i.v.) and BHT-920 (100 micrograms/kg i.v.) all suppressed FRA facilitated by DMI (3 mg/kg i.v.). The alpha-2 adrenoceptor antagonists yohimbine (100 micrograms/kg i.v.) and mianserin (30 micrograms/kg i.v.) antagonized the suppressant effect of clonidine (5 micrograms/kg i.v.) on DMI-facilitated FRA. Clonidine (10 micrograms/kg i.v.) had no effect on directly evoked twitches, and at 3-300 micrograms/kg i.v. had no effect on FRA facilitated by L-DOPA (100 mg/kg i.p.). It is suggested that DMI-facilitated FRA can be used as a test for alpha-2 adrenoceptor agonists which may act at presynaptic alpha-2 adrenoceptors in the spinal cord. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|