Cyclosporine therapeutic window evaluation by Chebyshev's inequality method in kidney recipients
| Autor: | Edmundas Kaduševičius, Franck Saint-Marcoux, Edgaras Stankevičius, Aurelija Noreikaitė |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Urology Bayesian estimator Young Adult Therapeutic index 616.61-089.843 [udc] Pharmacokinetics medicine Limited sampling Humans Kidney transplantation Cyclosporine Therapeutic use Aged Therapeutic window Medicine(all) Aged 80 and over Kidney lcsh:R5-920 business.industry Cyclosporine concentration Bayes Theorem Middle Aged medicine.disease Kidney Transplantation medicine.anatomical_structure Chebyshev's inequality Automotive Engineering Female business lcsh:Medicine (General) Immunosuppressive Agents |
| Zdroj: | Medicina, Vol 50, Iss 1, Pp 37-43 (2014) Medicina Volume 50 Issue 1 Pages 37-43 Medicina, Wrocław : Elsevier, 2014, vol. 50, no. 1, p. 37-43 Medicina; Volume 50; Issue 1; Pages: 37-43 |
| ISSN: | 1648-9144 1010-660X |
| Popis: | Objective: The aim of this study was to identify a cyclosporine therapeutic range for kidney recipients.Materials and methods: The cyclosporine exposure level was based on the calculation of the mean area under the concentration-time curve AUC(0–12). The AUC(0–12) was estimated using a Bayesian estimator and a 3-point limited sampling strategy. Cyclosporine exposure levels were obtained from 3 blood samples: 0, 1, and 3 h postdose and analyses were performed using a liquid chromatography–tandem mass spectrometry method. The therapeutic window of cyclosporine was calculated by the Chebyshev's inequality method with a 99% guarantee (a = 0.01) using the IBM SPSS Statistics 20 software.Results: It was found that the therapeutic window of cyclosporine estimated by the Cheby- shev's inequality method and put on the AUC(0–12) exposure lies in the ranges from 2.84– 3.13 mg h/L with the 99% confidence for the patients with the target AUC(0–12) exposure of 3.8 mg h/L (posttransplantation time > 1 year). The therapeutic window of cyclosporine differs in different posttransplantation time groups: the estimated AUC exposure range in the group of patients who have a graft longer than 5 years is 2.70–2.98 mg h/L, and the estimated AUC exposure range in the group of patients who have a graft for 1–5 years is 3.05–3.75 mg h/L.Conclusions: Chebyshev's inequality could be an appropriate and more precise method to determine the therapeutic window for cyclosporine in kidney recipients than the target AUC(0–12) value and further studies should be conducted to evaluate patients with postoperative time < 1 year. |
| Databáze: | OpenAIRE |
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