Quality of life and its association with comorbidities and adverse events from antiepileptic medications: Online survey of patients with epilepsy in Australia
Autor: | Lisa Todd, Alvin Ng, Christine Walker, Jeremy M Welton, Kate Riney, Wendyl D'Souza |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Cross-sectional study Pharmacy Comorbidity 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Quality of life Surveys and Questionnaires Medicine Humans 030212 general & internal medicine Adverse effect Depression (differential diagnoses) Sleep disorder Memory Disorders business.industry Mental Disorders Australia Middle Aged medicine.disease Cross-Sectional Studies Neurology Caregivers Quality of Life Anticonvulsants Female Neurology (clinical) Self Report business 030217 neurology & neurosurgery |
Zdroj: | Epilepsybehavior : EB. 104 |
ISSN: | 1525-5069 |
Popis: | This study aimed to explore the quality of life (QoL) of adult patients with epilepsy (PwE) in Australia and its relationship with comorbidities and adverse events (AEs) from antiepileptic drugs (AEDs).Cross-sectional surveys were completed by PwE, or carer proxies, recruited via the online pharmacy application MedAdvisor and Australian PwE Facebook groups from May to August 2018. Data were collected on demographics, epilepsy severity and management, AEs, comorbidities, and QoL (using the Patient-Weighted Quality of Life in Epilepsy Inventory [QOLIE-10-P] total score). Two linear regression models were constructed to explore associations between AEs or comorbidities and QOLIE-10-P score, with possible confounders determined using stepwise selection.Nine hundred and seventy-eight of 1267 responses were eligible (mean age of respondents: 44.5 years, 64% female, 52% employed). Recent AED use was reported by 97%; 47% were on AED monotherapy, 35% had ≤2 lifetime AEDs, and 55% were seizure-free for1 year. After stepwise selection, control variables included in both models were time since diagnosis, employment status, seizure frequency, number of currently prescribed AEDs, and number of general practitioner (GP) visits per year. In the model for comorbidities, "psychiatric disorders" was associated with the largest QOLIE-10-P score decrease (-23.14, p 0.001). In the model for AEs, which additionally controlled for depression and anxiety disorder, self-reported "memory problems" was associated with the largest decrease in QOLIE-10-P score (-14.27, p 0.001).In this survey of Australian PwE, many of whom had relatively well-controlled epilepsy, psychiatric and self-reported memory problems were common and associated with the greatest detrimental impact on QoL. Further research is needed to better understand the underlying causes of impaired QoL and thereby improve its management. |
Databáze: | OpenAIRE |
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