Efficacy of intervertebral disc regeneration with stem cells - a systematic review and meta-analysis of animal controlled trials
| Autor: | Jason S. Eldrige, Wenchun Qu, William D. Mauck, Khalid Benkhadra, Mathew J. Pingree, Khaled Mohammed, Jay Smith, Jason P. Dauffenbach, Andre J. van Wijnen, Shanmiao Gou, Zhen Wang, Marisa J. Terry, Randy A. Shelerud, Tai-Hua Yang, Mohammad Hassan Murad, Carman M. Perez-Terzic, Timothy P. Maus |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Intervertebral Disc Degeneration Biology law.invention Degenerative disease Randomized controlled trial law Internal medicine Genetics medicine Animals Humans Regeneration Intervertebral Disc Intervertebral disc General Medicine Stem-cell therapy medicine.disease Clinical trial Transplantation Disease Models Animal medicine.anatomical_structure Treatment Outcome Meta-analysis Stem cell Stem Cell Transplantation |
| Zdroj: | Gene. 564(1) |
| ISSN: | 1879-0038 |
| Popis: | Management of intervertebral disc (IVD) degenerative disease is challenging, as it is accompanied by irreversible loss of IVD cells. Stem cell transplantation to the disc has shown promise in decelerating or arresting the degenerative process. Multiple pre-clinical animal trials have been conducted, but with conflicting outcomes. To assess the effect of stem cell transplantation, a systematic review and meta-analysis was performed. A comprehensive literature search was conducted through Week 3, 2015. Inclusion criteria consisted of controlled animal trials. Two reviewers screened abstracts and full texts. Disagreements were resolved by a third reviewer. Random effects models were constructed to pool standardized mean difference (SMD). Twenty two studies were included; nine of which were randomized. Statistically significant differences were found with the stem cell group exhibiting increased disc height index (SMD=3.64, 95% confidence interval (CI): 2.49, 4.78; p |
| Databáze: | OpenAIRE |
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