Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid

Autor:	Francis F.Y. Lee, Fei You, Iontcho Radoslavov Vlahov, Stephen J. Howard, Paul J. Kleindl, Hari Krishna Santhapuram, Yu Wang, Gregory D. Vite, Christopher P. Leamon, Soong-Hoon Kim
Rok vydání:	2010
Předmět:	Epothilones Stereochemistry Clinical Biochemistry Pharmaceutical Science Peptide Antineoplastic Agents Epothilone Biochemistry Chemical synthesis Structure-Activity Relationship Folic Acid Cell Line Tumor Drug Discovery medicine Structure–activity relationship Animals Disulfides Molecular Biology chemistry.chemical_classification Organic Chemistry Folate Receptors GPI-Anchored Stereoisomerism Ligand (biochemistry) chemistry Folate receptor Molecular Medicine Linker medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 20(15)
ISSN:	1464-3405
Popis:	Efficient regioselective syntheses of conjugates of folic acid and cytotoxic agents derived from natural epothilones are described. These folate receptor (FR) targeting compounds are water soluble and incorporate a hydrophilic peptide-based spacer unit and a reducible self-immolative disulfide-based linker system between the FR-targeting ligand and the parent drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3a073ce6aa53e33ccca9a92b340779 https://pubmed.ncbi.nlm.nih.gov/20594844 Zobrazit plný text záznamu Full Text from ScienceDirect