Effects of glucocorticoids on pituitary hormonal responses to hypoglycemia. Inhibition of prolactin release
| Autor: | Marc L'Hermite, Raoul Leclercq, Georges Copinschi, Luc Vanhaelst, Jacqueline Golstein, E. Virasoro, Claude Robyn |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Blood Glucose Male endocrine system medicine.medical_specialty Time Factors Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Blood sugar Hypoglycemia Biochemistry Dexamethasone Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Humans Insulin business.industry Biochemistry (medical) Middle Aged medicine.disease Prolactin Stimulation Chemical Somatropin Growth Hormone business hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 40(3) |
| ISSN: | 0021-972X |
| Popis: | The characteristics of pituitary hormonal responses to insulin-induced hypoglycemia were investigated in 16 normal men. In all subjects, levels of blood sugar fell below 35 mg/100 ml. A statistically significant increase in mean plasma levels of prolactin, ACTH, cortisol and growth hormone was observed. Prolactin levels increased in all subjects but one; individual peak values were 1.4 minus 8.4 times greater than base levels. The kinetics of prolactin, GH and ACTH responses were similar; in particular, the onset of release (25 min) of prolactin, GH and ACTH was similar. After dexamethasone administration, insulin tolerance tests wererepeated in a number of subjects using adequate amounts of insulin to achieve hypoglycemia equivalent to that obtained in the control experiments. The administration of 1 mg of dexamethasone the evening before the test suppressed basal levels of ACTH and cortisol and the ACTH-but not the cortisol-response to hypoglycemia. Both basal levels of prolactin and prolactin response to hypoglycemia were significantly lowered but growth hormone response was not modified by administration of 1 mg of dexamethasone. The administration of larger doses of dexamethasone (1 mg every 6 h for 2 days) almost completely suppressed basal levels of ACTH, cortisol and prolactin, as well as the hypoglycemia-induced release of these hormones. In contrast, the growth hormone response to hypoglycemia was only partially inhibited. These findings demonstrate that both basal secretion and hypoglycemia-induced release of prolactin, ACTH, cortisol and growth hormone are suppressible by glucocorticoids. |
| Databáze: | OpenAIRE |
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