A genome‐wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study

Autor:	Sara R, Rashkin, Mario, Cleves, Gary M, Shaw, Wendy N, Nembhard, Eirini, Nestoridi, Mary M, Jenkins, Paul A, Romitti, Xiang-Yang, Lou, Marilyn L, Browne, Laura E, Mitchell, Andrew F, Olshan, Kevin, Lomangino, Sudeepa, Bhattacharyya, John S, Witte, Charlotte A, Hobbs
Rok vydání:	2022
Předmět:	Heart Defects Congenital Case-Control Studies Genetics Humans Infant Female Genetic Predisposition to Disease Polymorphism Single Nucleotide Genetics (clinical) Genome-Wide Association Study
Zdroj:	American Journal of Medical Genetics Part A. 188:2303-2314
ISSN:	1552-4833 1552-4825
Popis:	Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities, and epigenetic phenomena. A genome-wide association study was conducted in National Birth Defects Prevention Study participants (N
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d38308ef4b2aef43de19e8d1bbc3d63 https://doi.org/10.1002/ajmg.a.62759 Zobrazit plný text záznamu Plný text