Predictive factors of recurrence after pediatric acute pericarditis
| Autor: | Gordana Petrovic, Mila Stajevic, Sanja Ninic, Nemanja Djordjevic, Sergej Prijic, Vladislav Vukomanovic, Ivan Dizdarevic, Dejan Nesic, Ruzica Borovic, Stasa Krasic |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Myocarditis Gastroenterology Pediatrics RJ1-570 03 medical and health sciences chemistry.chemical_compound Pericarditis 0302 clinical medicine Acute pericarditis Recurrence 030225 pediatrics Internal medicine Medicine Colchicine Corticosteroids Humans 030212 general & internal medicine Child Retrospective Studies business.industry Erythrocyte sedimentation Anti-Inflammatory Agents Non-Steroidal Retrospective cohort study medicine.disease 3. Good health chemistry Pediatrics Perinatology and Child Health Acute Disease Etiology Recurrent pericarditis business |
| Zdroj: | Jornal de Pediatria, Volume: 97, Issue: 3, Pages: 335-341, Published: 02 JUL 2021 Jornal de Pediatria, Vol 97, Iss 3, Pp 335-341 (2021) Jornal de Pediatria v.97 n.3 2021 Jornal de Pediatria Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
| ISSN: | 1678-4782 |
| Popis: | Objective The predisposing factors for pericarditis recurrence in the pediatric population have not yet been established. This study aimed to define the risk factors for the unfavorable prognosis of pediatric acute pericarditis. Methods This was a retrospective study that included all patients with acute pericarditis treated from 2011 to 2019 at a tertiary referent pediatric center. Results The study included 72 children. Recurrence was observed in 22.2% patients. Independent risk factors for recurrence were: erythrocyte sedimentation rate ≥ 50 mm/h (p = 0.003, OR 186.3), absence of myocarditis (p = 0.05, OR 15.2), C-reactive protein ≥ 125 mg/L (p = 0.04, OR 1.5), and non-idiopathic etiology pericarditis (p = 0.003, OR 1.3). Corticosteroid treatment in acute pericarditis was associated with a higher recurrence rate than treatment with non-steroid anti-inflammatory therapy (p = 0.04). Furthermore, patients treated with colchicine in the primary recurrence had lower recurrence rate and median number of repeated infections than those treated without colchicine (p = 0.04; p = 0.007, respectively). Conclusion Independent risk factors for recurrence are absence of myocarditis, non-idiopathic etiology pericarditis, C-reactive protein ≥ 125 mg/L, and erythrocyte sedimentation rate ≥ 50 mm/h. Acute pericarditis should be treated with non-steroid anti-inflammatory therapy. A combination of colchicine and non-steroid anti-inflammatory drugs could be recommended as the treatment of choice in recurrent pericarditis. |
| Databáze: | OpenAIRE |
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