Magnesium content of erythrocytes in patients with vasospastic angina
| Autor: | Jiro Sugai, Masahiro Murayama, Kazuhiko Tanabe, Kiyohito Noda, Takehiko Mikawa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Angina Pectoris
Variant Male Erythrocytes medicine.medical_treatment chemistry.chemical_element Coronary Vasospasm Isosorbide Dinitrate Chest pain Angina Magnesium deficiency (medicine) medicine Humans Pharmacology (medical) Magnesium Aged Pharmacology Chemotherapy Vasospastic angina business.industry Vasospasm General Medicine Middle Aged medicine.disease Coronary Vessels chemistry Anesthesia Ergonovine Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular drugs and therapy. 5(4) |
| ISSN: | 0920-3206 |
| Popis: | The possibility that a magnesium deficiency might be the underlying cause of vasospastic angina (VA) and the efficacy of Mg administration in its treatment were studied. Subjects included 15 patients with VA and 18 healthy subjects as the control group. The erythrocyte Mg content was measured by atomic absorption, and serum Mg was measured by conventional chemical assay. The efficacy of Mg administration was studied in seven patients with VA. The results were as follows: a) The mean erythrocyte Mg content was less in the group with frequent episodes of angina (1.59 +/- 0.11 mg/dl) than in the group without angina (2.11 +/- 0.38 mg/dl, p less than 0.01) and in the control group (2.22 +/- 0.29 mg/dl, p less than 0.01). There was no significant difference between the control group and patients of each group with respect to serum Mg. b) Coronary arterial spasm was induced by ergonovine maleate in seven patients and was completely inhibited by the administration of Mg sulfate (40-80 mEq, hourly) in six of these patients; in the remaining patient neither obvious ST change nor chest pain occurred. Thus, it was concluded that the measurement of erythrocyte Mg content is useful to determine how easily vasospasm might occur in VA and that the administration of Mg might be developed as a new therapy for spasm associated with a low erythrocyte Mg content. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink