Chemical constituents from common vetch (Vicia sativa L.) and their antioxidant and cytotoxic activities
| Autor: | Wen-Hai Li, Li-Fang Liu, Cheng-Shan Yuan, Jia-Nan Xu, Xiao-Zhen Wu, Fan Yang, Man-Yu Li |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology Traditional medicine 010405 organic chemistry Chemistry DPPH Vicia sativa medicine.medical_treatment Organic Chemistry food and beverages Plant Science Coumarin biology.organism_classification 01 natural sciences Biochemistry Flavones 0104 chemical sciences Analytical Chemistry HeLa 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Phytochemical medicine Oleanane |
| DOI: | 10.6084/m9.figshare.7608941 |
| Popis: | Vicia sativa L. (common vetch) is a potential food source for both human beings and animals because of its abundant nutritional composition. There is a lack of phytochemical study on the whole plant, and thus the objective of this study was to investigate the isolation of phytochemicals and evaluate their biological activities. A new flavanol, (2R,3S)-3,3′-dihydroxy-4′,7-dimethoxyflavanol (1), together with nine known compounds, two flavones (2–3), one coumarin (4), and six oleanane triterpenoids (5–10), was obtained from Vicia sativa L.. The structure of the new compound 1 was determined via its NMR spectra, IR and CD data. Compound 3 displayed the potential of the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect in antioxidant test. In terms of cytotoxic activities, compound 3 showed moderate cytotoxic activities against three human tumor cells, especially HeLa cells. |
| Databáze: | OpenAIRE |
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