Effect of angiotensin II on histamine-induced bronchoconstriction in the human airway both in vitro and in vivo
| Autor: | Jane E. Nally, K. D. Dagg, R.A. Clayton, L.J. Thomson, S. G. Ramsay, Neil C. Thomson |
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| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Bronchi Bronchial Provocation Tests Bronchoconstrictor Agents chemistry.chemical_compound Double-Blind Method In vivo Internal medicine Forced Expiratory Volume medicine Humans Respiratory system Aged Bronchus Analysis of Variance Dose-Response Relationship Drug business.industry Angiotensin II Middle Aged medicine.disease Asthma Dose–response relationship Endocrinology medicine.anatomical_structure chemistry Acute severe asthma Bronchoconstriction Female medicine.symptom business Histamine |
| Zdroj: | Respiratory medicine. 91(10) |
| ISSN: | 0954-6111 |
| Popis: | The renin-angiotensin system is activated in acute severe asthma. Angiotensin II causes bronchoconstriction in mild asthmatics and potentiates methacholine-evoked bronchoconstriction both in vitro and in vivo.To evaluate the effect of angiotensin II on histamine-induced bronchoconstriction, human bronchial rings (n=6) were obtained from lung tissue at thoracotomy and were prepared in organ baths. Contractions were measured isometrically and cumulative concentration-response curves obtained to angiotensin II alone and to histamine in the presence and absence of threshold concentrations of angiotensin II.Eight asthmatic patients with bronchial hyper-reactivity to histamine were challenged with histamine during intravenous infusion of placebo, angiotensin II 1 ng kg−1 min−1 and angiotensin II 2 ng kg−1 min−1 administered in a randomized, double-blind fashion. FEV1 was measured prior to, during the infusion and during the histamine challenge.Angiotensin II (3 × 10−7 m and 10−6 m) alone evoked small contractions ( |
| Databáze: | OpenAIRE |
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