The Effect of Tranexamic Acid and Gender on Intraoperative Bleeding in Orthognathic Surgery-A Randomized Controlled Trial
| Autor: | Else Marie Pinholt, Johannes Jakobsen Sidelmann, Jesper Jared Secher, Janne Ingerslev, Jens Jørgen Thorn |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Denmark Orthognathic surgery Blood Loss Surgical Placebo Antifibrinolytic Agents/therapeutic use law.invention 03 medical and health sciences Orthognathic Surgical Procedures 0302 clinical medicine Blood loss Randomized controlled trial Double-Blind Method law Medicine Humans Saline business.industry 030206 dentistry Antifibrinolytic Agents Surgery Treatment Outcome Otorhinolaryngology Tranexamic Acid 030220 oncology & carcinogenesis Anesthesia Population study Female Oral Surgery business Tranexamic acid Blood Loss Surgical/prevention & control Tranexamic Acid/therapeutic use medicine.drug |
| Zdroj: | Jared Secher, J, Sidelmann, J J, Ingerslev, J, Thorn, J J & Pinholt, E M 2018, ' The effect of Tranexamic acid and Gender on Intraoperative Bleeding in Orthognathic Surgery : A Randomized Controlled Trial ', Journal of Oral and Maxillofacial Surgery, vol. 76, no. 6, pp. 1327-1333 . https://doi.org/10.1016/j.joms.2017.11.015 |
| ISSN: | 1531-5053 |
| DOI: | 10.1016/j.joms.2017.11.015 |
| Popis: | Purpose: The purpose of this randomized trial was to measure the effect of intravenously administered tranexamic acid (TXA) on intraoperative blood loss (IOB) in patients undergoing bimaxillary orthognathic surgery (OS). Materials and Methods: The authors designed and implemented a double-blinded placebo-controlled trial composed of patients eligible for OS at the Hospital of South West Denmark (Esbjerg, Denmark) from August 2014 through September 2016. The primary predictor variable was a single intravenous dose of TXA 1 g administered preoperatively or an equivalent saline placebo. The primary outcome was IOB determined by milliliters of blood in the suction canister and gauzes deducted from the volume of saline used intraoperatively. Results: The study population consisted of 96 patients. The TXA group (n = 51) and the placebo group (n = 45) showed a median IOB of 275 and 403 mL (P =.005), respectively. A significant effect of TXA was detected in women (median IOB, 153 mL [96 to 233 mL] in TXA group vs 329 mL [185 to 582 mL] in placebo group; P |
| Databáze: | OpenAIRE |
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