Exploration in the Mechanism of Action of Licorice by Network Pharmacology
| Autor: | Huijuan Gan, Jie Kang, Yuxing Gao, Fafu Yang, Meimei Chen, Jingru Zhu, Xinmei Lai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Pharmaceutical Science Computational biology Biology Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences Structure-Activity Relationship 0302 clinical medicine food lcsh:Organic chemistry licorice target identification Network pharmacology Drug Discovery medicine Glycyrrhiza Physical and Theoretical Chemistry KEGG network analysis 030304 developmental biology food additive 0303 health sciences Molecular Structure Plant Extracts Food additive Organic Chemistry KEGG pathway analysis Kegg pathway analysis chEMBL Mechanism of action Chemistry (miscellaneous) 030220 oncology & carcinogenesis Food products Molecular Medicine Food Additives medicine.symptom Oral retinoid Drugs Chinese Herbal |
| Zdroj: | Molecules Molecules, Vol 24, Iss 16, p 2959 (2019) Volume 24 Issue 16 |
| ISSN: | 1420-3049 |
| Popis: | Licorice is a popular sweetener and a thirst quencher in many food products particularly in Europe and the Middle East and also one of the oldest and most frequently used herbs in traditional Chinese medicine. As a wide application of food additive, it is necessary to clarify bioactive chemical ingredients and the mechanism of action of licorice. In this study, a network pharmacology approach that integrated drug-likeness evaluation, structural similarity analysis, target identification, network analysis, and KEGG pathway analysis was established to elucidate the potential molecular mechanism of licorice. First, we collected and evaluated structural information of 282 compounds in licorice and found 181 compounds that met oral drug rules. Then, structural similarity analysis with known ligands of targets in the ChEMBL database (similarity threshold = 0.8) was applied to the initial target identification, which found 63 compounds in licorice had 86 multi-targets. Further, molecular docking was performed to study their binding modes and interactions, which screened out 49 targets. Finally, 17 enriched KEGG pathways (p < 0.01) of licorice were obtained, exhibiting a variety of biological activities. Overall, this study provided a feasible and accurate approach to explore the safe and effective application of licorice as a food additive and herb medicine. |
| Databáze: | OpenAIRE |
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