THE INHIBITORY RESPONSE OF THE RABBIT ANOCOCCYGEUS MUSCLE
| Autor: | San San Wai, Ian M. Coupar |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Physiology Dimethylphenylpiperazinium In Vitro Techniques chemistry.chemical_compound Physiology (medical) Internal medicine Muscarinic acetylcholine receptor medicine Animals Drug Interactions Phenylephrine Pharmacology Tetraethylammonium Muscles Acetylcholine Electric Stimulation Atropine Endocrinology Nicotinic agonist chemistry Female Hexamethonium Rabbits Muscle Contraction medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 3:141-145 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1976.tb00598.x |
| Popis: | SUMMARY 1. Strips of rabbit anococcygeus muscle were submaximally contracted by the addition of phenylephrine to the bath fluid. 2. Acetylcholine, dimethylphenylpiperazinium and electrical field stimulation caused relaxation. Relaxation induced by acetylcholine and field stimulation was blocked by tetrodotoxin but only the acetylcholine-induced response was inhibited by lignocaine, tetraethylammonium and hexamethonium. The responses to both acetylcholine and field stimulation were resistant to atropine, practolol, and sotalol. 3. Relatively high concentrations of ATP caused relaxation. 4. Histological investigation did not show any cells resembling autonomic ganglion cells. 5. It is suggested that both acetylcholine and field stimulation release an inhibitory transmitter from nerve endings and that the release by acetylcholine is mediated through nicotinic receptor stimulation. |
| Databáze: | OpenAIRE |
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