A Murine Model for Listerial Meningitis and Meningoencephalomyelitis: Therapeutic Evaluation of Drugs in Mice
| Autor: | R S Hirth, Y H Tsai, F Leitner |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Chlortetracycline
medicine.drug_class Antibiotics Meningitis Listeria Erythromycin medicine.disease_cause Microbiology Mice Listeria monocytogenes Central Nervous System Diseases Meningoencephalitis Drug Discovery medicine Animals Pharmacology (medical) Encephalomyelitis Pharmacology biology business.industry General Medicine Minocycline Amoxicillin medicine.disease biology.organism_classification Anti-Bacterial Agents Disease Models Animal Infectious Diseases Oncology Immunology Listeria business Meningitis medicine.drug |
| Zdroj: | Chemotherapy. 26:196-206 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000237905 |
| Popis: | Meningitis and meningoencephalomyelitis caused by Listeria monocytogenes were experimentally established in mice. The pathological changes in brain and spinal cord resulting from the infection resemble those observed in man and domestic animals. The efficacy of 24 antibiotics in treating this experimental infection was determined. Minocycline and chlortetracycline were the most efficacious antiotics followed by amoxicillin, which was 2- to 4-fold less active than the former. However, the acute toxicity of amoxicillin to the murine central nervous system was at least 10-fold lower than that of the tetracyclines. Since parenteral amoxicillin may be of value in the management of listerial meningitis and meningoencephalomyelitis in man and domestic animals, clinical trials seem warranted. |
| Databáze: | OpenAIRE |
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