Diethylstilbestrol exposure during pregnancy with primary clear cell carcinoma of the cervix in an 8-year-old granddaughter: a multigenerational effect of endocrine disruptors?
| Autor: | Samir Hamamah, Arnauld Verschuur, Nathalie Cassel-Knipping, Laura Gaspari, Charles Sultan, Xavier Carcopino-Tusoli, Marie-Odile Soyer-Gobillard, Françoise Paris, Julia Villeret, Nicolas Kalfa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Diethylstilbestrol Cervix Uteri Endocrine Disruptors Cervical Clear Cell Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Vaginal bleeding Clear-cell adenocarcinoma Child Cervix 030304 developmental biology 0303 health sciences Obstetrics business.industry Rehabilitation Obstetrics and Gynecology medicine.disease medicine.anatomical_structure Reproductive Medicine Prenatal Exposure Delayed Effects 030220 oncology & carcinogenesis Clear cell carcinoma Vagina Female Neoplasm Recurrence Local medicine.symptom business Adenocarcinoma Clear Cell medicine.drug |
| Zdroj: | Human Reproduction. |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/deaa267 |
| Popis: | To date, vaginal/cervical clear cell adenocarcinoma (CCAC) has not been reported in the granddaughters of women treated with diethylstilbestrol (DES) during pregnancy. We present an 8-year-old girl with a history of severe vaginal bleeding who was diagnosed with cervical CCAC. She underwent fertility-sparing surgery and radiotherapy. No sign of recurrence was detected throughout a 10-year follow-up. Her grandmother had received DES therapy during pregnancy with the patient’s mother. Although no direct causal link is demonstrated, this case raises for the first time, the hypothesis of multigenerational effects of DES in girls and strongly suggests the need to follow the granddaughters of DES-treated women. |
| Databáze: | OpenAIRE |
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