Molecular changes track recurrence and progression of bronchial precancerous lesions
| Autor: | Maria Oggionni, Silvana Pilotti, Luca Tavecchio, Gabriella Sozzi, L. Alasio, Giuseppe Calarco, Davide Conte, Pasquale Spinelli |
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| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Genetic Markers Male Cancer Research Pathology medicine.medical_specialty Lung Neoplasms Disease Risk Assessment Bronchoscopy medicine Humans Longitudinal Studies Risk factor Lung cancer Aged Bronchus medicine.diagnostic_test business.industry Respiratory disease medicine.disease Acid Anhydride Hydrolases Neoplasm Proteins Natural history medicine.anatomical_structure Oncology Disease Progression Neoplasm Recurrence Local Tumor Suppressor Protein p53 Risk assessment business Precancerous Conditions |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 37(3) |
| ISSN: | 0169-5002 |
| Popis: | Diagnosis of lung cancer is reached when the disease had grown to advanced stages in its natural history. Thus, novel molecular markers for early detection and risk assessment are needed. Here we performed a longitudinal study of 20 morphological lesions occurred in the bronchial tree of high-risk patients. The lesions were subjected to LIFE (laser-induced fluorescence endoscopy) bronchoscopy and molecular follow-up over a 4 year period. The presence and the persistence of specific genetic alterations were correlated with recurrence or progression of the disease on follow-up. Molecular lesions considered as highly predictive of invasion could be prospectively used as diagnostic markers of high risk for lung cancer in exposed patients. |
| Databáze: | OpenAIRE |
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