The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines
| Autor: | Qing Yao, Xinlu Lin, Ruijie Chen, Youting Zhang, Xinyu Jiang, Huirong Huang, Longfa Kou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer therapy
xCT/SLC7A11 Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences Review article medicine Treatment resistance Pharmacology chemistry.chemical_classification Membrane transporter Reactive oxygen species Redox homeostasis Chemistry lcsh:RM1-950 ROS Redox homeostasis Cancer Transporter 021001 nanoscience & nanotechnology medicine.disease Cancer metabolism 0104 chemical sciences Cell biology Nanomedicine lcsh:Therapeutics. Pharmacology Tumor progression 0210 nano-technology |
| Zdroj: | Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 2, Pp 145-157 (2020) Asian Journal of Pharmaceutical Sciences |
| ISSN: | 1818-0876 |
| DOI: | 10.1016/j.ajps.2020.02.001 |
| Popis: | Tumor cell usually exhibits high levels of reactive oxygen species and adaptive antioxidant system due to the metabolic, genetic, and microenvironment-associated alterations. The altered redox homeostasis can promote tumor progression, development, and treatment resistance. Several membrane transporters are involved in the resetting redox homeostasis and play important roles in tumor progression. Therefore, targeting the involved transporters to disrupt the altered redox balance emerges as a viable strategy for cancer therapy. In addition, nanomedicines have drawn much attention in the past decades. Using nanomedicines to target or reset the redox homeostasis alone or combined with other therapies has brought convincing data in cancer treatment. In this review, we will introduce the altered redox balance in cancer metabolism and involved transporters, and highlight the recent advancements of redox-modulating nanomedicines for cancer treatment. Graphical abstract Tumor cells exhibits high levels of reactive oxygen species and adaptive antioxidant system, beneficial to tumor progression, development, and treatment resistance. Nanomedicine targeting to disrupt the adaptive redox balance emerges as a viable strategy for cancer therapy.Image, graphical abstract |
| Databáze: | OpenAIRE |
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