Biomonitoring of blood cholinesterases and acylpeptide hydrolase activities in rural inhabitants exposed to pesticides in the Coquimbo Region of Chile

Autor: Liliana Zúñiga-Venegas, Koos van der Velden, Cristián Farías-Gómez, Paul T.J. Scheepers, Nel Roeleveld, Rodrigo Sandoval, Muriel Ramírez-Santana, Floria Pancetti
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Rural Population
Physiology
lcsh:Medicine
Biochemistry
Geographical locations
chemistry.chemical_compound
0302 clinical medicine
Animal Cells
Red Blood Cells
Blood plasma
Biomonitoring
Medicine and Health Sciences
Public and Occupational Health
Chile
Enzyme Inhibitors
lcsh:Science
Butyrylcholinesterase
Cognitive Impairment
Multidisciplinary
Cognitive Neurology
Agriculture
Environmental exposure
Middle Aged
Acetylcholinesterase
Body Fluids
Blood
Neurology
language
Female
Cellular Types
Anatomy
Agrochemicals
Environmental Monitoring
Research Article
Adult
Adolescent
Aché
Cognitive Neuroscience
Biology
Blood Plasma
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
03 medical and health sciences
Young Adult
Humans
Pesticides
Chile (Country)
Blood Cells
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
lcsh:R
Biology and Life Sciences
Environmental Exposure
Cell Biology
Pesticide
South America
language.human_language
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
030104 developmental biology
chemistry
APEH
Enzymology
Cognitive Science
lcsh:Q
Pest Control
People and places
030217 neurology & neurosurgery
Biomarkers
Peptide Hydrolases
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0196084 (2018)
PLoS One, 13, 5
PLoS One, 13
ISSN: 1932-6203
Popis: Contains fulltext : 196738.pdf (Publisher’s version ) (Open Access) In Chile, agriculture is a relevant economic activity and is concomitant with the use of pesticides to improve the yields. Acute intoxications of agricultural workers occur with some frequency and they must be reported to the surveillance system of the Ministry of Health. However the impacts of chronic and environmental pesticide exposure have been less studied. Among pesticides frequently used in Chile for insects control are organophosphates (OP) and carbamates (CB). They are inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In this study we determined the pattern of both biomarkers activity in three populations with different type of chronic exposure to OP/CB: environmentally exposed (EE), occupationally exposed (OE) and a reference group (RG) without exposure. Besides this, we also measured the activity of acylpeptide hydrolase (APEH), an enzyme involved in relevant functions in the central synapses that is also expressed in erythrocytes and previously reported to be highly inhibited by some OP. A baseline measurement was done in both exposure groups and then a second measurement was done during the spraying season. The RG was measured only once at any time of the year. Our results indicate that people under chronic OP/CB exposure showed an adaptive response through an increase of basal BChE activity. During the spray season only BChE activity was decreased in the EE and OE groups (p
Databáze: OpenAIRE
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