CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
| Autor: | James G. Fox, Prashant R. Nambiar, Varada P. Rao, David B. Schauer, Susan E. Erdman, Jane J. Sohn, Zhongming Ge |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adenoma
CD4-Positive T-Lymphocytes Male Cancer Research Genes APC Tumor suppressor gene Ratón Colorectal cancer Down-Regulation Apoptosis Biology medicine.disease_cause Immunotherapy Adoptive Interferon-gamma Mice Prostate Intestinal Neoplasms medicine Animals IL-2 receptor RNA Messenger Tumor Necrosis Factor-alpha Cancer medicine.disease Interleukin-10 Mice Inbred C57BL medicine.anatomical_structure Oncology Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Immunology Carcinogenesis |
| Zdroj: | Cancer research. 65(10) |
| ISSN: | 0008-5472 |
| Popis: | Colorectal cancer in humans results from sequential genetic changes in intestinal epithelia commencing with inactivation of the APC tumor suppressor gene. Roles for host immunity in epithelial tumorigenesis are poorly understood. It has been previously shown that CD4+CD25+ lymphocytes inhibit colitis-associated epithelial tumors in Rag-deficient mice. Here we show that addition of CD4+CD25+ lymphocytes in ApcMin/+ mice reduces multiplicity of epithelial adenomas. Interleukin-10 was required in regulatory cells for therapeutic effect. Recipients of regulatory cells showed increased apoptosis and down-regulation of cyclooxygenase-2 within tumors coincident with tumor regression. These data suggest a role for regulatory lymphocytes in epithelial homeostasis in the ApcMin/+ mouse model of intestinal polyposis. Similarities with cancer of the breast, prostate, lung, and other sites raise the possibility of broader roles for regulatory lymphocytes in prevention and treatment of epithelial cancers in humans. |
| Databáze: | OpenAIRE |
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