Levofloxacin and Ciprofloxacin Decrease Procainamide and N -Acetylprocainamide Renal Clearances
| Autor: | Douglas J. Black, Jennifer S. Lill, Larry A. Bauer, Thomas M. Hooton, Vidmantas A. Raisys, Julie A. Garrison |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Ofloxacin Renal function Levofloxacin Procainamide Pharmacology Kidney Pharmacokinetics Ciprofloxacin medicine Humans Acecainide Drug Interactions Pharmacology (medical) Antibacterial agent Cross-Over Studies business.industry biochemical phenomena metabolism and nutrition bacterial infections and mycoses Crossover study Anti-Bacterial Agents Infectious Diseases medicine.anatomical_structure Female business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 49:1649-1651 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.49.4.1649-1651.2005 |
| Popis: | Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N -acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed ( P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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