Origin and evolution of circular waves and spirals in Dictyostelium discoideum territories
| Autor: | Edward C. Cox, Eirikur Palsson |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
CAMP phosphodiesterase inhibitor
Cell Communication Models Biological Dictyostelium discoideum Quantitative Biology::Cell Behavior Quantitative Biology::Subcellular Processes Cell Movement Cyclic AMP Animals Dictyostelium Glycoproteins Mathematics Multidisciplinary biology Ecology Temporal noise Cell movement biology.organism_classification Kinetics Wavelength 3' 5'-Cyclic-AMP Phosphodiesterases Biophysics Signal Transduction Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 93:1151-1155 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.93.3.1151 |
| Popis: | Randomly distributed Dictyostelium discoideum cells form cooperative territories by signaling to each other with cAMP. Cells initiate the process by sending out pulsatile signals, which propagate as waves. With time, circular and spiral patterns form. We show that by adding spatial and temporal noise to the levels of an important regulator of external cAMP levels, the cAMP phosphodiesterase inhibitor, we can explain the natural progression of the system from randomly firing cells to circular waves whose symmetries break to form double- and single- or multi-armed spirals. When phosphodiesterase inhibitor is increased with time, mimicking experimental data, the wavelength of the spirals shortens, and a proportion of them evolve into pairs of connected spirals. We compare these results to recent experiments, finding that the temporal and spatial correspondence between experiment and model is very close. |
| Databáze: | OpenAIRE |
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