Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm
| Autor: | Chin Mu Hsu, Ying Ju Lin, Yao Yuan Hsieh, Chi Chen Chang, Fuu Jen Tsai, Ming Min Lo, Kung Hao Hsu, Da Yuan Chen |
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| Rok vydání: | 2010 |
| Předmět: |
Genetic Markers
Male Microbiology (medical) medicine.medical_specialty Clinical Biochemistry Human leukocyte antigen Mucocutaneous Lymph Node Syndrome Biology Polymorphism Single Nucleotide Pathogenesis Molecular genetics Genotype medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Child Allele frequency Chi-Square Distribution Biochemistry (medical) Haplotype Coronary Aneurysm Public Health Environmental and Occupational Health Proteins Original Articles Hematology medicine.disease Medical Laboratory Technology Haplotypes HLA-B Antigens Child Preschool Immunology Chromosomes Human Pair 6 Female Kawasaki disease Molecular Chaperones |
| Zdroj: | Journal of Clinical Laboratory Analysis. 24:262-268 |
| ISSN: | 1098-2825 0887-8013 |
| DOI: | 10.1002/jcla.20409 |
| Popis: | Capsule: HLA‐B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations. Objective: KD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno‐inflammatory process, cytokines activation, and genetic factors. We aimed to investigate if genetic variants of human lymphocyte antigen (HLA)‐BAT2, 3, and 5 (BAT2, 3, and 5) could be used as markers of susceptibility in KD and CAA. Methods: Individuals were divided into three groups: (1) normal controls; (2) KD with CAA; and (3) KD without CAA. Polymorphisms for BAT2 (−8671, 16483), BAT3 (8854, 2–24), and BAT5 (22655, 9569) were genotyped by PCR system with TaqMan allelic discrimination assay. Genotype/allelic frequencies and haplotypes (BAT2(−8671)‐BAT2(16483)‐BAT3(8854)‐BAT3(2–24)‐BAT5(22655)‐BAT5(9569)) in each group were compared. Results: Genotype distribution and allele frequency of BAT2 −8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms in each group were significantly different. BAT2 −8671*G, BAT3 8854*C, BAT5 22655*C, and 9569*A‐related genotypes and alleles are correlated with the developments of KD and CAA. BAT haplotypes of ATTGTG and ATCATG are associated with higher susceptibilities of KD with CAA susceptibility. Conclusion: BAT2 −8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms as well as BAT haplotypes (ATTGTG and ATCATG) might be associated with higher KD susceptibility and CAA formation. HLA‐B region polymorphisms might contribute to the pathogenesis of KD and CAA. J. Clin. Lab. Anal. 24:262–268, 2010. © 2010 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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