Advanced Role of Hippo Signaling in Endometrial Fibrosis: Implications for Intrauterine Adhesion
| Autor: | Yi-Bin Pan, Tian-Xiang Ge, Haiyan Zhu, Songying Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Regulator lcsh:Medicine Review Article 03 medical and health sciences Endometrium Intrauterine Adhesion 0302 clinical medicine Hippo Signaling Fibrosis Transforming Growth Factor beta medicine Humans Endometrial Fibrosis Transforming Growth Factor-β Wnt Signaling Uterine Diseases Hippo signaling pathway 030219 obstetrics & reproductive medicine business.industry lcsh:R Wnt signaling pathway General Medicine Fibroblasts medicine.disease 030104 developmental biology Hippo signaling Cancer research Female Signal transduction business Myofibroblast Transforming growth factor Signal Transduction |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 130, Iss 22, Pp 2732-2737 (2017) |
| ISSN: | 2542-5641 |
| Popis: | Objective: Intrauterine adhesion (IUA) is a major health problem that causes infertility, menstrual irregularities, and recurrent pregnancy losses in women. Unfortunately, treatments for IUA are limited, and there are currently no effective strategies for preventing IUA recurrence. In this review, we introduced the role of Hippo signaling in the normal endometrium and IUA and described the mechanisms by which the Hippo pathway integrates with the Wnt and transforming growth factor-β (TGF-β) signaling pathways to form an intricate network governing the development of fibrosis. Data Sources: Original research articles in English that were published until July 2017 were collected from the PubMed database. Study Selection: Literature search was conducted using the search terms "endometrial fibrosis OR fibrosis AND or OR intrauterine adhesion OR Asherman syndrome OR IUA," "Hippo AND or OR Hippo/TAZ," "TGF-β," and "Wnt." Related original research articles were included in the comprehensive analysis. Results: Endometrial fibrosis is recognized as a key pathological event in the development of IUA, which is characterized by epithelial/fibroblast–myofibroblast transition. Myofibroblasts play crucial roles in the pathogenesis of fibrous scarring, and myofibroblast differentiation can be triggered by multiple signaling pathways. Hippo signaling is a critical regulator of the epithelial/fibroblast–myofibroblast transition and α-smooth muscle actin, which exhibits a specific spatiotemporal expression in the endometrium. Conclusions: Hippo signaling plays a critical role in fibrous diseases and participates in cross talks with Wnt and TGF-β signaling. Our findings not only contributed to knowledge on the pathogenesis of endometrial fibrosis, but can also serve as a useful resource for developing specific molecular inhibitors for IUA treatment and prevention. Key words: Endometrial Fibrosis; Hippo Signaling; Intrauterine Adhesion; Transforming Growth Factor-β; Wnt Signaling |
| Databáze: | OpenAIRE |
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