A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation
| Autor: | Megan L. Falsetta, David C. Foster, Richard P. Phipps, Adrienne Bonham |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Vulvar pain Vulvodynia Inflammatory response Pain Inflammation Dinoprostone Article Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine medicine Humans Interleukin 6 030219 obstetrics & reproductive medicine biology Interleukin-6 business.industry Obstetrics and Gynecology Fibroblasts medicine.disease Inflammatory mediator Immunology biology.protein Female Inflammation Mediators medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | BJOG: An International Journal of Obstetrics & Gynaecology. 124:210-218 |
| ISSN: | 1470-0328 |
| DOI: | 10.1111/1471-0528.14157 |
| Popis: | Localised provoked vulvodynia (LPV) is a common, chronic, and disabling condition: patients experience profound pain and a diminished quality of life. The aetiologic origins of vulvodynia are poorly understood, yet recent evidence suggests a link to site-specific inflammatory responses. Fibroblasts isolated from the vestibule of LPV patients are sensitive to proinflammatory stimuli and copiously produce pain-associated proinflammatory mediators (IL-6 and PGE2). Although LPV is a multifactorial disorder, understanding vulvar inflammation and targeting the inflammatory response should lead to treatment advances, especially for patients exhibiting signs of inflammation. NFκB (already targeted clinically) or other inflammatory components may be suitable therapeutic targets. Tweetable abstract Vulvodynia is a poorly understood, prevalent, and serious women's health issue requiring better understanding to improve therapy. |
| Databáze: | OpenAIRE |
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