Belief, delusion, hypnosis, and the right dorsolateral prefrontal cortex: A transcranial magnetic stimulation study
| Autor: | Max Coltheart, Rochelle E. Cox, Vince Polito, Amanda J. Barnier, Robyn Langdon, Paul F. Sowman, Emily Connaughton, Nikolas Williams, Hannah L. Morgan, Lina Teichmann |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Hypnosis Cognitive systems Adolescent Hallucinations Cognitive Neuroscience medicine.medical_treatment Movement Prefrontal Cortex Experimental and Cognitive Psychology Trust 050105 experimental psychology Delusions Functional Laterality 03 medical and health sciences Young Adult 0302 clinical medicine Cognition Delusion medicine Humans 0501 psychology and cognitive sciences Suggestion 05 social sciences Neuropsychology Bayes Theorem Transcranial Magnetic Stimulation Transcranial magnetic stimulation Dorsolateral prefrontal cortex Neuropsychology and Physiological Psychology medicine.anatomical_structure Cortical Excitability Right dorsolateral prefrontal cortex Female medicine.symptom Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Cortex; a journal devoted to the study of the nervous system and behavior. 101 |
| ISSN: | 1973-8102 |
| Popis: | According to the Two-Factor theory of delusional belief (see e.g. Coltheart at al., 2011), there exists a cognitive system dedicated to the generation, evaluation, and acceptance or rejection of beliefs. Studies of the neuropsychology of delusion provide evidence that this system is neurally realized in right dorsolateral prefrontal cortex (rDLPFC). Furthermore, we have shown that convincing analogues of many specific delusional beliefs can be created in nonclinical subjects by hypnotic suggestion and we think of hypnosis as having the effect of temporarily interfering with the operation of the belief system, which allows acceptance of the delusional suggestions. If the belief system does depend on rDLPFC, then disrupting the activity of that region of the brain by the application of repetitive transcranial magnetic stimulation (rTMS) will increase hypnotizability. Dienes and Hutton (2013) have reported such an experiment except that it was left DLPFC to which rTMS was applied. An effect on a subjective measure of hypnotizability was observed, but whether there was an effect on an objective measure could not be determined. We report two experiments. The first was an exact replication of the Dienes and Hutton experiment; here we found no effect of rTMS to lDLPFC on any hypnotic measure. Our second experiment used rTMS applied to right rather then left DLPFC. This right-sided stimulation enhanced hypnotizability (when hypnotic response was measured objectively), as predicted by our hypothesis. These results imply a role for rDLPFC in the cognitive process of belief evaluation, as is proposed in our two-factor theory of delusion. They are also consistent with a conception of the acceptance of a hypnotic suggestion as involving suspension of disbelief. |
| Databáze: | OpenAIRE |
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