A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

Autor:	John B. Cheng, Ajith V. Kamath, Douglas A. Fisher, Kelvin Lam, R. J. Chambers, Joann D. Pillar, Tessa A. Castleberry, Kristin Abrams, David Nettleton, John P. Umland, J.T. Shirley, C R Turner, Anthony Marfat, Alissa L. Sheils, E. D. Salter
Rok vydání:	2006
Předmět:	Niacinamide Phosphodiesterase Inhibitors Clinical Biochemistry Pharmaceutical Science Biochemistry Isozyme chemistry.chemical_compound Drug Discovery Leukocytes medicine Molecular Biology Rolipram chemistry.chemical_classification Nicotinamide Chemotaxis Organic Chemistry respiratory system Eosinophil Cyclic Nucleotide Phosphodiesterases Type 4 Eosinophils Isoenzymes Enzyme medicine.anatomical_structure chemistry Mechanism of action 3' 5'-Cyclic-AMP Phosphodiesterases Molecular Medicine medicine.symptom Function (biology) medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 16:718-721
ISSN:	0960-894X
Popis:	Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d23e0f0dd362554a78f820bb3c0f7b6 https://doi.org/10.1016/j.bmcl.2005.10.026 Zobrazit plný text záznamu Full Text from ScienceDirect