Anti-Müllerian hormone as a predictor of reproductive potential
| Autor: | Anne Z. Steiner, Leah Hawkins Bressler |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Anti-Mullerian Hormone Infertility endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism media_common.quotation_subject Population Physiology Fertility 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Internal Medicine medicine Humans 030212 general & internal medicine Ovarian Reserve Ovarian reserve education media_common education.field_of_study 030219 obstetrics & reproductive medicine Nutrition and Dietetics biology urogenital system business.industry Reproduction Anti-Müllerian hormone Prognosis medicine.disease female genital diseases and pregnancy complications Menopause Cohort biology.protein Female business Infertility Female Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Current Opinion in Endocrinology & Diabetes and Obesity. 25:385-390 |
| ISSN: | 1752-296X |
| DOI: | 10.1097/med.0000000000000440 |
| Popis: | Purpose of review Anti-Mullerian hormone (AMH), a marker of ovarian reserve, declines over a woman's reproductive lifespan. AMH is highly correlated with a woman's age and number of primordial ovarian follicles, and has been shown to predict time to menopause in women in their 40s. For these reasons, it was assumed that AMH levels could predict a woman's reproductive potential or serve as a 'fertility test'. Recently, studies have sought to determine the association between AMH and fertility. Recent findings Although a small, prospective, time-to-pregnancy study of 98 women suggested that an AMH level less than 0.7 ng/ml was associated with lower day-specific probabilities of conception, the follow-up, larger cohort did not identify an association with AMH and fecundability. Women with AMH values less than 0.7 ng/ml had similar pregnancy rates after 12 cycles of attempting to conceive as women with normal AMH values after adjusting for age. Four additional studies, including a secondary analysis of the NICHD EAGER trial including over 1200 women confirmed these findings. Summary Although AMH is a marker of ovarian reserve, existing literature does not support the use of AMH as a marker of reproductive potential in the general population. |
| Databáze: | OpenAIRE |
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