IL-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients
| Autor: | Mao‑Xiao Yan, Wei Wu, Hua Jiang, Ying Li |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Oncogene medicine.medical_treatment Cell Cancer Articles Biology Cell cycle medicine.disease Molecular medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytokine medicine.anatomical_structure Oncology Apoptosis 030220 oncology & carcinogenesis Interleukin 35 medicine |
| Zdroj: | Oncology letters. 13(5) |
| ISSN: | 1792-1074 |
| Popis: | Interleukin-35 (IL-35) has been proposed as a novel immune-suppressing cytokine. However, the function of IL-35 in malignant diseases is yet to be elucidated. The present study investigated IL-35 expression levels in laryngeal squamous cell carcinoma (LSCC) tissues and the peripheral blood of patients to explore the potential involvement of IL-35 in LSCC progression. In the present study, IL-35 expression levels in tissues and peripheral blood were analyzed by reverse transcription-quantitative polymerase chain reaction and an enzyme-linked immunosorbent assay. The association between IL-35 expression levels and clinical characteristics was also evaluated. The present results demonstrated that IL-35 expression in tumor tissues was significantly higher than in adjacent normal tissues, and a significant association between IL-35 expression levels in tissues and the tumor site was detected. Furthermore, the expression of IL-35 in the peripheral blood of patients was significantly decreased subsequent to tumor resection. No correlation between peripheral blood IL-35 expression and clinical characteristics was detected. In conclusion, the present study demonstrated that IL-35 is highly expressed in LSCC tissues and in the peripheral blood of patients with LSCC. There was a notable, significant reduction of peripheral blood IL-35 expression following surgical resection of tumors. These results may be useful for diagnostic or therapeutic purposes in patients with LSCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|