Severe chronic nonlichenoid oral mucositis in pembrolizumab-treated patients: new cases and a review of the literature
| Autor: | Ori Finfter, Akram Shalabi, Yonatan Birenzweig, Yehuda Zadik, Dalit Porat Ben Amy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Adolescent Drug-Related Side Effects and Adverse Reactions medicine.medical_treatment Immunology Pembrolizumab Adenocarcinoma Astrocytoma Antibodies Monoclonal Humanized Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological medicine Mucositis Immunology and Allergy Humans 030212 general & internal medicine Mucocele Low-Level Light Therapy Low level laser therapy Aged 80 and over Stomatitis business.industry Brain Neoplasms Cancer medicine.disease Dermatology Oncology Withholding Treatment 030220 oncology & carcinogenesis Chronic Disease Immunotherapy business Oral medicine Anaplastic astrocytoma |
| Zdroj: | Immunotherapy. 12(11) |
| ISSN: | 1750-7448 |
| Popis: | Aim: To report of severe chronic oral mucositis (OM) in two pembrolizumab-treated cancer patients. Materials & methods: A retrospective chart review was performed. Inclusion/exclusion criteria detected patients that developed OM during pembrolizumab immunotherapy. In addition, we searched the literature for nonlichenoid OM in immunotherapy-treated cancer patients. Results: Two male patients treated for anaplastic astrocytoma and lung adenocarcinoma were included. Extensive painful OM (grade 4) developed in both patients during the course of immunotherapy and the ulcerations remained >30 weeks (>16 weeks after stopping immunotherapy). Superficial mucocele appeared in one patient. In one patient, pain relief was achieved with photobiomodulation (low-level laser) therapy. Conclusion: OM induced by immunotherapy may be a major cause of suffering and eating difficulties. In most cases, the OM lasted for months even after the drug was stopped. There is a controversy regarding the beneficial effect of corticosteroids on OM in these patients. |
| Databáze: | OpenAIRE |
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