Diverse roles of Synaptotagmin-7 in regulating vesicle fusion
| Autor: | Vincent Huson, Wade G. Regehr |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Calcium metabolism Vesicle fusion General Neuroscience Vesicle chemistry.chemical_element Lipid bilayer fusion Calcium Neurotransmission Membrane Fusion Synaptic Transmission Article Synaptotagmin 1 Synaptotagmins 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Neurotransmitter Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Curr Opin Neurobiol |
| ISSN: | 0959-4388 |
| DOI: | 10.1016/j.conb.2020.02.006 |
| Popis: | Synaptotagmin 7 (Syt7) is a multifunctional calcium sensor expressed throughout the body. Its high calcium affinity makes it well suited to act in processes triggered by modest calcium increases within cells. In synaptic transmission, Syt7 has been shown to mediate asynchronous neurotransmitter release, facilitation, and vesicle replenishment. In this review we provide an update on recent developments, and the newly emerging roles of Syt7 in frequency invariant synaptic transmission and in suppressing spontaneous release. Additionally, we discuss Syt7's regulation of membrane fusion in non-neuronal cells, and its involvement in disease. How such diversity of functions is regulated remains an open question. We discuss several potential factors including temperature, presynaptic calcium signals, the localization of Syt7, and its interaction with other Syt isoforms. |
| Databáze: | OpenAIRE |
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