Response to growth hormone-releasing hormone in adult renal failure patients on hemodialysis
| Autor: | Connie W. Ayers, Polly A. Bittle, German Ramirez, Arunabha Ganguly, Barry B. Bercu |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyrotropin Growth Hormone-Releasing Hormone Follicle-stimulating hormone Basal (phylogenetics) Endocrinology Renal Dialysis Internal medicine Medicine Humans Insulin-Like Growth Factor I Aged business.industry Luteinizing Hormone Middle Aged Growth hormone–releasing hormone Somatomedin Prolactin Peptide Fragments Kinetics Growth Hormone Kidney Failure Chronic Hemodialysis Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Metabolism: clinical and experimental. 39(7) |
| ISSN: | 0026-0495 |
| Popis: | Exogenous synthetic growth hormone-releasing hormone (GHRH [hpGRF-40]), 1 microgram/kg body weight, was administered intravenously (IV) to eight men with chronic renal failure on chronic hemodialysis and to seven men matched for age (control group). Basal and stimulated growth hormone (GH) concentrations following GHRH (hpGRF-40) in renal failure patients were significantly higher than in controls. Basal prolactin and somatomedin C/insulin-like growth factor-1 (SmC/IGF-1) concentrations were significantly higher in the renal failure patients compared with controls. Following GHRH there was no further increase in serum concentration of thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, SmC/IGF-1, or cortisol. GH appears to be the only pituitary hormone where there is an exaggerated response to its specific releasing hormone in adults with renal failure. |
| Databáze: | OpenAIRE |
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