Chronic splenomegaly in Nairobi, Kenya. II. Portal hypertension
| Autor: | R.A. Jupp, B Slavin, B.M. Wankya, T. K. Arap Siongok, Kevin M. De Cock, S.B. Lucas, J. Bertrand, R. S. Raja, S. Awadh, P.H. Rees |
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| Rok vydání: | 1987 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Schistosomiasis Esophageal and Gastric Varices Gastroenterology Tropical splenomegaly syndrome Esophageal varices Internal medicine Hypertension Portal Medicine Humans Hepatitis B Surface Antigens medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health General Medicine Hepatitis B medicine.disease Hepatitis B Core Antigens Kenya Schistosomiasis mansoni Infectious Diseases Liver biopsy Splenomegaly Portal hypertension Parasitology business Varices |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 81(1) |
| ISSN: | 0035-9203 |
| Popis: | Eighty-five patients with chronic splenomegaly and proven oesophageal varices were studied at Kenyatta National Hospital, Nairobi. The major defined groups were hepatosplenic schistosomiasis (24%), cirrhosis (20%) and portal vein occlusion (11%). Hyper-reactive malarial splenomegaly (tropical splenomegaly syndrome) was considered as the cause of oesophageal varices in only one patient. In 26% of cases liver biopsy was non-diagnostic and the extrahepatic portal vein was demonstrated radiologically to be patent. Such patients were thought to be suffering from idiopathic portal hypertension, not previously described elsewhere in Africa. Hepatitis B surface antigen was detected in 12% of controls and in 58% of patients with cirrhosis (p less than 0.001). Some serological marker of previous hepatitis B virus infection was present in 92% of patients with cirrhosis and in 79% of controls. Kamba patients from Machakos and Kitui Districts were significantly more prevalent than expected among these 85 cases of portal hypertension. |
| Databáze: | OpenAIRE |
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