The Efficacy and Safety of Gonadotropin-Releasing Hormone Analog Treatment in Childhood and Adolescence: A Single Center, Long-Term Follow-Up Study
| Autor: | Marina Papadaki, Marina Vakaki, Niki Lalioti, Maria Alexandra Magiakou, Christina Kanaka-Gantenbein, Dimitrios Hadjidakis, George Piaditis, Catherine Dacou-Voutetakis, George P. Chrousos, Athanassios Papaefstathiou, Despoina Manousaki, Georgia Levidou |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Puberty Precocious Single Center Biochemistry Cohort Studies Gonadotropin-Releasing Hormone Young Adult Endocrinology Internal medicine Humans Medicine Young adult Child Growth Disorders Bone mineral Triptorelin Pamoate Human Growth Hormone business.industry Biochemistry (medical) medicine.disease Obesity Idiopathic short stature Drug Combinations Luteolytic Agents Treatment Outcome El Niño Female business Body mass index Follow-Up Studies Cohort study |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 95:109-117 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2009-0793 |
| Popis: | The objective of the study was to evaluate the long-term effect of GnRH analog (GnRHa) treatment on final height (FH), body mass index (BMI), body composition, bone mineral density (BMD), and ovarian function.Ninety-two females, evaluated in adulthood, were categorized as follows: group A, 47 girls with idiopathic central precocious puberty (33 GnRHa treated and 14 nontreated); group B, 24 girls with isolated GH deficiency (15 GnRHa and GH treated and nine GH treated); group C, 21 girls with idiopathic short stature (seven GnRHa and GH treated, seven GnRHa treated, and seven nontreated).FH, BMD, and percent fat mass of GnRHa-treated patients in all three groups were comparable with those of the respective nontreated subjects. BMI values of GnRHa-treated and nontreated subjects in groups A and C were comparable, whereas in group B, a higher BMI was found in subjects treated only with GH. Nontreated patients with ICPP had greater maximal ovarian volumes, higher LH and LH to FSH ratio, and more severe hirsutism than GnRHa-treated ones. Menstrual cycle characteristics were not different between treated and nontreated subjects. The prevalence of polycystic ovary syndrome in treated and untreated girls with ICPP was comparable, whereas in the entire cohort, it was 11.1% in GnRHa treated and 32.1% in the untreated (P = 0.02).Girls treated in childhood with GnRHa have normal BMI, BMD, body composition, and ovarian function in early adulthood. FH is not increased in girls with ICPP in whom GnRHa was initiated at about 8 yr. There is no evidence that GnRHa treatment predisposes to polycystic ovary syndrome or menstrual irregularities. |
| Databáze: | OpenAIRE |
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