Interferon-τ increases BoLA-I for implantation during early pregnancy in dairy cows
| Autor: | Zhe Zhu, Xiao Wang, Yue Wu, Binbin Li, GanZhen Deng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
TRAF3 medicine.medical_specialty medicine.medical_treatment interferon-τ nidation Early pregnancy factor Human leukocyte antigen BoLA-I 03 medical and health sciences 0302 clinical medicine Internal medicine medicine early pregnancy Pregnancy 030219 obstetrics & reproductive medicine Interferon τ biology business.industry dairy cow Embryo Immunosuppression medicine.disease 030104 developmental biology Endocrinology Cytokine Oncology biology.protein business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.19282 |
| Popis: | Interferon-τ (IFN-τ) signals pregnancy recognition in ruminants. We investigated the effects of IFN-τ produced by embryo trophoblastic cells (ETCs) on expression of bovine leukocyte antigen-I (BoLA-I), a bovine analogue of human MHC-I, in endometrial luminal epithelial cells (EECs) during early pregnancy in dairy cows. Expression of IFN-τ and BoLA-I was increased in endometrial tissues during early pregnancy. Expression of the anti-inflammatory cytokine IL-10 was increased in endometrial tissues, while expression of the pro-inflammatory cytokine IL-6 was decreased, indicating immunosuppression. Progesterone increased IFN-τ expression in EECs. IFN-τ increased p-STAT1 and p-STAT3 levels in EECs, but reduced TRAF3 levels. In addition, IFN-τ increased expression of BoLA-I and IL-10, but decreased expression of IL-6 in EECs. These results indicate that IFN-τ enables stable implantation in dairy cows by increasing expression of BoLA-I, and by immunosuppression mediated by increased IL-10 and decreased IL-6 expression. |
| Databáze: | OpenAIRE |
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