Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement

Autor: Phioanh L. Nghiemphu, Tania Kaprealian, Matthew Ji, Whitney B. Pope, Albert Lai, Catalina Raymond, Nicholas S. Cho, Chencai Wang, Timothy F. Cloughesy, Noriko Salamon, Benjamin M. Ellingson
Rok vydání: 2020
Předmět:
Male
Cancer Research
Pathology
Neurology
animal diseases
medicine.medical_treatment
0302 clinical medicine
Lateral Ventricles
Cancer
Brain Neoplasms
Middle Aged
Neural stem cell
Radiation therapy
Treatment Outcome
medicine.anatomical_structure
Apparent diffusion coefficient
Oncology
030220 oncology & carcinogenesis
Biomedical Imaging
Female
medicine.medical_specialty
Subventricular zone
Oncology and Carcinogenesis
Brain tumor
Article
03 medical and health sciences
Rare Diseases
Clinical Research
medicine
Humans
Effective diffusion coefficient
Oncology & Carcinogenesis
Aged
business.industry
Neurosciences
Diffusion weighted imaging
medicine.disease
Brain Disorders
Brain Cancer
body regions
Diffusion Magnetic Resonance Imaging
nervous system
Neurology (clinical)
Glioblastoma
business
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: J Neurooncol
Journal of neuro-oncology, vol 147, iss 3
ISSN: 1573-7373
0167-594X
DOI: 10.1007/s11060-020-03460-5
Popis: IntroductionThere is growing evidence that the subventricular zone (SVZ) plays a key role in glioblastoma (GBM) tumorigenesis. However, little is known regarding how the SVZ, which is a harbor for adult neural stem cells, may be influenced by chemoradiation. The current diffusion-weighted imaging (DWI) study explored ipsilateral and contralateral alterations in the anterior SVZ in GBM patients with posterior enhancing lesions following chemoradiation.MethodsForty GBM patients with tumor involvement in the posterior SVZ (mean age = 57 ± 10; left-hemisphere N = 25; right-hemisphere N = 15) were evaluated using DWI before and after chemoradiation. Regions-of-interest were drawn on the ipsilesional and contralesional anterior SVZ on apparent diffusion coefficient (ADC) maps for both timepoints. ADC histogram analysis was performed by modeling a bimodal, double Gaussian distribution to obtain ADCL, defined as the mean of the lower Gaussian distribution.ResultsThe ipsilesional SVZ had lower ADCL values compared to the contralesional SVZ before treatment (mean difference = 0.025 μm2/ms; P = 0.007). Following chemoradiation, these changes were no longer observed (mean difference = 0.0025 μm2/ms; P > 0.5), as ADCL values of the ipsilesional SVZ increased (mean difference = 0.026 μm2/ms; P = 0.037). An increase in ipsilesional ADCL was associated with shorter progression-free (P = 0.0119) and overall survival (P = 0.0265).ConclusionsThese preliminary observations suggest baseline asymmetry as well as asymmetric changes in the SVZ proximal (ipsilesional) to the tumor with respect to contralesional SVZ regions may be present in GBM, potentially implicating this region in tumorigenesis and/or treatment resistance.
Databáze: OpenAIRE
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