ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases
| Autor: | Antonio Schmandke, Stephen M. Strittmatter, Andre Schmandke |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Central Nervous System
rho GTP-Binding Proteins 0301 basic medicine Dendritic spine Lipoproteins Nogo Proteins Receptor Protein-Tyrosine Kinases Nerve Tissue Proteins GTPase Biology Article Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Animals Humans Receptors Immunologic Cytoskeleton Neurons rho-Associated Kinases Kinase General Neuroscience Cell migration Actin cytoskeleton Cell biology 030104 developmental biology Neurology (clinical) Signal transduction Cell Adhesion Molecules Protein Processing Post-Translational Neuroscience Myelin Proteins 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | The Neuroscientist. 13:454-469 |
| ISSN: | 1089-4098 1073-8584 |
| Popis: | Rho-associated protein kinases (ROCKs) play key roles in mediating the control of the actin cytoskeleton by Rho family GTPases in response to extracellular signals. Such signaling pathways contribute to diverse neuronal functions from cell migration to axonal guidance to dendritic spine morphology to axonal regeneration to cell survival. In this review, the authors summarize biochemical knowledge of ROCK function and categorize neuronal ROCK-dependent signaling pathways. Further study of ROCK signal transduction mechanisms and specificities will enhance our understanding of brain development, plasticity, and repair. The ROCK pathway also provides a potential site for therapeutic intervention to promote neuronal regeneration and to limit degeneration. NEUROSCIENTIST 13(5):454—469, 2007. |
| Databáze: | OpenAIRE |
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