Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains

Autor:	Sarah C. Abbot, Christine S. Chan, Sharon M. Dankwardt, Chris Allen Broka, Keith A. M. Walker, Harold E. Van Wart, Eric B. Springman, Robert L. Martin
Rok vydání:	2002
Předmět:	Stereochemistry Carboxylic acid Clinical Biochemistry Pharmaceutical Science Hydroxamic Acids Biochemistry Chemical synthesis Bone Morphogenetic Protein 1 chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Side chain Protease Inhibitors Amino Acids Molecular Biology chemistry.chemical_classification Sulfonamides Hydroxamic acid Organic Chemistry Metalloendopeptidases Procollagen N-Endopeptidase Sulfonamide Amino acid Procollagen peptidase chemistry Bone Morphogenetic Proteins Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 12(8)
ISSN:	0960-894X
Popis:	Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition, novel carboxylic acid sulfonamides were discovered to be PCP inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d114f4b680f08370ec702afb8776563 https://pubmed.ncbi.nlm.nih.gov/11934595 Zobrazit plný text záznamu Full Text from ScienceDirect