Mortality and morbidity in obstructive sleep apnoea–hypopnoea syndrome: results from a 30-year prospective cohort study
| Autor: | Linda Williams, Marjorie Vennelle, Renata L. Riha, Sophie Dodds, Serafeim-Chrysovalantis Kotoulas, Amber Roguski, Neil J. Douglas |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pediatrics medicine.medical_specialty business.industry Incidence (epidemiology) medicine.medical_treatment lcsh:R MEDLINE lcsh:Medicine Original Articles Disease Anthropometry Sleep in non-human animals respiratory tract diseases Medicine Continuous positive airway pressure Sleep business Prospective cohort study Cohort study |
| Zdroj: | ERJ Open Research, Vol 6, Iss 3 (2020) ERJ Open Research article-version (VoR) Version of Record Dodds, S, Williams, L J, Roguski, A, Vennelle, M, Douglas, N J, Kotoulas, S-C & Riha, R L 2020, ' Mortality and morbidity in obstructive sleep apnoea-hypopnoea syndrome : results from a 30-year prospective cohort study ', ERJ Open Research, vol. 6, no. 3 . https://doi.org/10.1183/23120541.00057-2020 |
| ISSN: | 2312-0541 |
| Popis: | Background Obstructive sleep apnoea–hypopnoea syndrome (OSAHS) carries substantial negative health consequences. This study examines factors affecting mortality and morbidity according to continuous positive airway pressure (CPAP) use and predictors affecting CPAP adherence in a longitudinal cohort of OSAHS patients. Materials and methods This prospective, cohort study comprised 4502 patients who were diagnosed with OSAHS at a tertiary sleep disorders centre between 1982 and 2003. Of these, 1174 patients completed follow-up in 2012. Data collected included anthropometric, sleep and demographic characteristics, including comorbidities, ongoing medications and CPAP adherence. Patients were followed up for an average of 14.8±3.7 years. Results Imputation analysis showed that long-term CPAP users (>5 years) were 5.63 times more likely to be alive at study end than non-CPAP users (95% CI: 4.83–6.58, p In this first long-term prospective cohort study to use imputation analysis in OSAHS patients, all-cause morbidity and mortality were significantly reduced in long-term CPAP users (>5 years), and equivalent for both males and females https://bit.ly/3cKL2HK |
| Databáze: | OpenAIRE |
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