Pluripotent steroidogenesis and ultrastructure in adrenocortical adenomas causing Cushing's syndrome
| Autor: | Alan N. Elias, Lubomir J. Valenta, Krish Iyer |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adenoma
Adult medicine.medical_specialty Pathology medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Cushing syndrome Endocrinology Zona fasciculata Adrenal Cortex Hormones Internal medicine medicine Adrenal adenoma Humans Gonadal Steroid Hormones Cushing Syndrome Adrenal cortex medicine.disease Adrenal Cortex Neoplasms Steroid hormone Microscopy Electron medicine.anatomical_structure Mineralocorticoid Female Glucocorticoid medicine.drug |
| Zdroj: | Hormone research. 25(2) |
| ISSN: | 0301-0163 |
| Popis: | Adrenal vein catheterization data from 2 patients with adrenocortical adenomas causing Cushing’s syndrome are presented and the electron-microscopic features of one of the tumors are described. Based on the catheterization data both tumors produced all three classes of adrenal steroids (mineralocorticoids, glucocorticoids and sex steroids). Electron-microscopic examination of the tumor cells suggested an origin from the zona fasciculata. If one accepts the theory of a common cellular origin of adrenal tumors, then the pattern of steroidogenesis would indicate that the postulated original ‘stem’ cell retains the potential of secreting all classes of adrenocortical steroids. The clinical presentation of such tumors would thus reflect the hypersecretion of one of the steroid classes relative to the others. |
| Databáze: | OpenAIRE |
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