Determinants of Visfatin/NAMPT Serum Concentration and its Leukocyte Expression in Hyperthyroidism
| Autor: | Bartłomiej Budny, Ariadna Zybek-Kocik, Kosma Woliński, Jerzy Sowiński, Michał Kloska, Katarzyna Ziemnicka, Dorota Mańkowska-Wierzbicka, Agata Czarnywojtek, Marek Ruchała, Nadia Sawicka-Gutaj |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Goiter endocrine system diseases Cross-sectional study Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Nicotinamide phosphoribosyltransferase Adipose tissue 030209 endocrinology & metabolism Trab Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Leukocytes medicine Humans Euthyroid RNA Messenger Nicotinamide Phosphoribosyltransferase business.industry Biochemistry (medical) Toxic nodular goiter General Medicine Middle Aged medicine.disease Graves Disease Cross-Sectional Studies Gene Expression Regulation chemistry 030220 oncology & carcinogenesis Cytokines Female business Goiter Nodular |
| Zdroj: | Hormone and Metabolic Research. 50:653-660 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/a-0669-1584 |
| Popis: | We aimed to analyze the potential influence of thyroid autoimmunity on visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients. This is a single-center, cross-sectional study with consecutive enrollment. All patients with newly diagnosed overt hyperthyroidism in a course of Graves' disease or toxic nodular goiter were included in the study. They underwent physical examination, laboratory investigation, body composition analysis, and thyroid ultrasound. NAMPT mRNA leukocyte expressions were measured using RT-qPCR. Of the 173 patients, 95 were enrolled in further analysis [67 patients with Graves' disease (GD) and 28 with toxic nodular goiter (TNG)]. Control group consisted of 43 healthy volunteers adjusted for age, sex, and BMI. Higher NAMPT/visfatin serum concentration was found in patients with GD comparing with patients with TNG (p=0.03855). We found significant NAMPT leukocyte overexpression in GD patients (n=32) as compared to TNG patients (n=18) and euthyroid controls (n=24) (p=0.005965). Simple linear regression analysis revealed that NAMPT/visfatin serum concentration was significantly associated with NAMPT leukocyte expression, thyroid autoimmunity, age, HOMA-IR, and fat mass percentage (FM%). NAMPT leukocyte expression was related to thyroid autoimmunity, age, and TRAb levels. The stepwise multiple regression analysis revealed FM% and HOMA-IR as independent predictors of visfatin/NAMPT serum levels. In a separate stepwise multiple regression analysis, we confirmed the association between NAMPT leukocyte expression and TRAb levels. We found that fat mass percentage together with HOMA-IR are the most significant predictors of visfatin/NAMPT serum elevation in hyperthyroid patients. |
| Databáze: | OpenAIRE |
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