Survival after Locoregional Recurrence or Second Primary Breast Cancer: Impact of the Disease-Free Interval
| Autor: | A.B.G. Kwast, Gabe S. Sonke, Sabine Siesling, Annemieke Witteveen, Maarten Joost IJzerman |
|---|---|
| Přispěvatelé: | Health Technology & Services Research, Faculty of Behavioural, Management and Social Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Younger age medicine.medical_treatment Population Improved survival lcsh:Medicine Breast Neoplasms Kaplan-Meier Estimate Disease-Free Survival Breast cancer Surgical oncology Internal medicine medicine Humans education lcsh:Science Aged Proportional Hazards Models Gynecology Chemotherapy education.field_of_study Multidisciplinary Disease free interval Proportional hazards model business.industry Health Policy lcsh:R Public Health Environmental and Occupational Health Neoplasms Second Primary Second primary cancer Middle Aged medicine.disease Prognosis Cancer registry Radiation therapy METIS-310806 IR-96221 Hormonal therapy lcsh:Q Female Neoplasm Recurrence Local business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, 10(4):e0120832. Public Library of Science PLoS ONE, Vol 10, Iss 4, p e0120832 (2015) |
| ISSN: | 1932-6203 |
| Popis: | The association between the disease-free interval (DFI) and survival after a locoregional recurrence (LRR) or second primary (SP) breast cancer remains uncertain. The objective of this study is to clarify this association to obtain more information on expected prognosis. Women first diagnosed with early breast cancer between 2003–2006 were selected from the Netherlands Cancer Registry. LRRs and SP tumours within five years of first diagnosis were examined. The five-year period was subsequently divided into three equal intervals. Prognostic significance of the DFI on survival after a LRR or SP tumour was determined using Kaplan-Meier estimates and multivariable Cox regression analysis. Follow-up was complete until January 1, 2014. A total of 37,278 women was included in the analysis. LRRs or SP tumours were diagnosed in 890 (2,4%) and 897 (2,4%) respectively. Longer DFI was strongly and independently related to an improved survival after a LRR (long versus short: HR 0.65, 95% CI 0.48–0.88; medium versus short HR 0.81, 95% CI 0.65–1.01). Other factors related to improved survival after LRR were younger age ( |
| Databáze: | OpenAIRE |
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