Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP)
| Autor: | Emiko Ishiwata, Chieko Ishiwata, Kazushige Kiguchi, Hiroshi Ishikawa, Toshiaki Tachibana, Hisashi Hashimoto, Isamu Ishiwata, Yoshiro Sato |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Choroid Plexus Neoplasms Cancer Research Pathology medicine.medical_specialty Time Factors Chromosome number Mice Nude Aneuploidy Biology Mice Antigens Neoplasm Cell Line Tumor medicine Animals Humans Doubling time Cell Proliferation Mice Inbred BALB C Plexus Contact inhibition Glioma Cell Biology Anatomy medicine.disease Culture Media Cell culture Karyotyping Papilloma Female Neoplasm Transplantation |
| Zdroj: | Human Cell. 18:67-72 |
| ISSN: | 0914-7470 |
| DOI: | 10.1111/j.1749-0774.2005.tb00059.x |
| Popis: | A cell line designated "HIBSPP" was established from a human malignant choroids plexus papilloma of 29-year-old Japanese woman. This line grew well without interruption for 3 years and was subcultivated over 70 times. The cells were spindle, oval, and polygonal in shape, and neoplastic and pleomorphic features, a jigsaw puzzle-like arrangement, multilayering and forming papillary structures without contact inhibition. The cells proliferated slowly, and the population doubling time was about 69 hours. The chromosome number showed a wide distribution of aneuploidy. The mode was in the hypotetraploid range, and many marker chromosomes were observed. The culture cells were easily transplanted into the subcutis of nude mice and produced the tumor resembling the original tumor. |
| Databáze: | OpenAIRE |
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