Age of onset in chronic major depression: relation to demographic and clinical variables, family history, and treatment response
| Autor: | Wilma Harrison, Martin B. Keller, Robert H Howland, Daniel Goodman, Lisa M. LaVange, A. John Rush, Michael E. Thase, Frank Dowling, Alan F. Schatzberg, Christine M.N. Smith, Daniel N. Klein, James P. McCullough, John C. Markowitz |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Imipramine medicine.medical_specialty Comorbidity Antidepressive Agents Tricyclic medicine Humans Age of Onset Family history Major depressive episode Psychiatry Depression (differential diagnoses) Aged Demography Family Health Depressive Disorder Middle Aged Prognosis medicine.disease Personality disorders Psychiatry and Mental health Clinical Psychology Treatment Outcome Mood disorders Major depressive disorder Female medicine.symptom Age of onset Psychology |
| Zdroj: | Journal of Affective Disorders. 55:149-157 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/s0165-0327(99)00020-8 |
| Popis: | Background : The clinical and etiological significance of the early–late onset distinction in chronic major depressive disorder was explored. Method : Subjects were 289 outpatients with DSM-III-R chronic major depression drawn from a multi-site study comparing the efficacy of sertraline and imipramine in the acute and long-term treatment of chronic depression. Patients received comprehensive evaluations using semi-structured interviews and rating scales. Results : Early-onset chronic major depression was associated with a longer index major depressive episode and higher rates of recurrent major depressive episodes, comorbid personality disorders, lifetime substance use disorders, depressive personality traits, and a history of psychiatric hospitalization. In addition, more early-onset patients tended to have a family history of mood disorders. The early-late onset distinction was not associated with differences in symptom severity, functional impairment, or treatment response. Limitations : Family members were not interviewed directly; there were a large number of statistical comparisons; and interrater reliability of the assessments was not evaluated. Conclusions : Early-onset chronic major depression has a more malignant course and is associated with greater comorbidity than late-onset chronic major depression. |
| Databáze: | OpenAIRE |
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