Applications of Gelatin Methacryloyl (GelMA) Hydrogels in Microfluidic Technique-Assisted Tissue Engineering
| Autor: | Wenxian Weng, Xiaoting Sun, Yuzhuo Zhang, Huazhe Yang, Taotao Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
food.ingredient Biocompatibility Tissue mimicking phantom Microfluidics microfluidics biomedicine Pharmaceutical Science Nanotechnology Biocompatible Materials 02 engineering and technology Review 010402 general chemistry 01 natural sciences Gelatin Analytical Chemistry lcsh:QD241-441 Magnetics Mice food Tissue engineering lcsh:Organic chemistry Lab-On-A-Chip Devices Neoplasms Drug Discovery Materials Testing Animals Humans Physical and Theoretical Chemistry Cell Proliferation Tissue Engineering Tissue Scaffolds Organic Chemistry Bioprinting Hydrogels Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology Gelatin methacrylate Coculture Techniques 0104 chemical sciences GelMA hydrogels Microfluidic chip Chemistry (miscellaneous) Self-healing hydrogels Printing Three-Dimensional Disease Progression Molecular Medicine 0210 nano-technology |
| Zdroj: | Molecules Molecules, Vol 25, Iss 5305, p 5305 (2020) |
| ISSN: | 1420-3049 |
| Popis: | In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed. |
| Databáze: | OpenAIRE |
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