Pitfalls in estimating piperaquine elimination

Autor:	Michael Ashton, Nicholas J. White, Joel Tarning, Anna Annerberg, Niklas Lindegardh, T Singtoroj, Nicholas P. J. Day
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Pharmacology business.industry Sensitivity and Specificity Antimalarials Infectious Diseases Piperaquine Healthy volunteers Quinolines Medicine Animals Humans Pharmacology (medical) Pharmaceutical sciences business Half-Life
Popis:	By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d04d62fff9091609ff19fd1b8242712 https://ora.ox.ac.uk/objects/uuid:d38fef1a-f5c7-42b9-bc5e-99abef55a3ae Zobrazit plný text záznamu