Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS
| Autor: | Astrid van Tubergen, Ivette Essers, Filip van den Bosch, Désirée van der Heijde, Marc Blaauw, Maxime Dougados, Sofia Ramiro, Robert Landewé, Carmen Stolwijk |
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| Přispěvatelé: | Interne Geneeskunde, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Severity of Illness Index Cohort Studies Rheumatology anterior uveitis inflammatory bowel disease Internal medicine Psoriasis Severity of illness ankylosing spondylitis medicine Odds Ratio Humans Pharmacology (medical) Genetic Predisposition to Disease Spondylitis Ankylosing HLA-B27 Antigen Retrospective Studies Ankylosing spondylitis business.industry Hazard ratio Age Factors Retrospective cohort study Odds ratio psoriasis Middle Aged medicine.disease Inflammatory Bowel Diseases Uveitis Anterior Surgery Cohort Acute Disease Female business Cohort study |
| Zdroj: | Rheumatology, 54(4), 633-640 Rheumatology, 54(4), 633-640. Oxford University Press |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | OBJECTIVE: The aim of this study was to identify characteristics associated with the presence and development of extra-articular manifestations (EAMs) in a prevalence cohort of patients with AS. METHODS: Twelve-year follow-up data from the Outcome in Ankylosing Spondylitis International Study (OASIS) were used. In addition, medical charts were checked for the presence of acute anterior uveitis (AAU), IBD and psoriasis. Demographic, clinical and radiographic characteristics associated with the presence of (any) EAM at baseline or new development during follow-up were identified. RESULTS: Two hundred and sixteen patients were included [mean age 43.6 years (s.d. 12.7), 154 (71%) men, mean symptom duration 20.5 years (s.d. 11.7), mean follow-up 8.3 years (s.d. 4.3)]. At baseline, 39 (18%) patients had AAU, 15 (7%) had IBD and 9 (4%) had psoriasis. The history of AAU was univariably associated with increased age [odds ratio (OR) 1.04 (95% CI 1.01, 1.07)], longer symptom duration [OR 1.05 (95% CI 1.02, 1.08)] and more radiographic damage [OR 1.02 (95% CI 1.00, 1.04)]. The history of psoriasis was associated with greater age [OR 1.05 (95% CI 1.00, 1.11)] and lower CRP [OR 0.77 (95% CI 0.59, 1.00)]. At follow-up, 27 patients developed a new EAM. Newly developed IBD was associated with a higher time-varying AS Disease Activity Score [hazard ratio (HR) 2.80 (95% CI 1.43, 5.52)], worse physical function [HR 1.40 (95% CI 1.09, 1.80)] and worse patient global well-being [HR 1.46 (95% CI 1.10, 1.93)]. Newly developed AAU was associated with an elevated time-varying CRP [HR 1.02 (95% CI 1.01, 1.04)]. CONCLUSION: Development of EAMs was infrequent in this cohort, despite relatively long follow-up. In particular, markers of disease activity were associated with the development of IBD. |
| Databáze: | OpenAIRE |
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